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Reproductive toxicity studies of D-camphor in rats and rabbits. It has been reported that topical exposure of gingival tissue to sea cucumber extract SCE over three months was safe [ 77 ]. Am J Pathol. A poisoning of topical importance. J Agric Food Chem. Eur Spine J. Eur J Inter Med.

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Leuschner J.

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Birth weight, gestational age and medications during pregnancy. However, to date, there have been no reported deaths caused by topical use of eucalyptus oil. Although some studies reported that MSM can cross the placenta resulting in higher concentrations in the fetal plasma [ 14 ], to date, there have been no human data on adverse reproductive effects. Similarly, adverse drug reactions were minimal in a study that evaluated the efficacy of MSM in reduction of symptoms associated with allergic rhinitis [ 12 ].

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Thus, the aim of the current article was to review the available evidence related to fetal safety of PTMC ingredients and to create an evidence-based framework for PTMC use during pregnancy and lactation.

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